Table 1 Model parameters TA

Cost tiotropium (per 4 week cycle) (U$)

71

89

53

Annual cost of health state asthma controlled (U$)

38

47

28

[19]

Annual cost of health state OCS burst (per episode) (U$)

38

47

28

Annual cost of health state ED visit (per episode) (U$)

2648

3310

1986

Annual cost of health state hospitalization (per episode) (U$)

230

288

173

Utilities (annual)

Utility of controlled state

0.740

0.93

0.56

[13]

Utility decrement

Exacerbations requiring OCS burst

0.1

0.13

0.08

[14]

Exacerbations requiring ED visit

0.15

0.19

0.11

Exacerbations requiring hospitalization

0.2

0.25

0.15

Tiotropium effect

Relative risk on exacerbation rate

0.72

0.83

0.62

[12]

Exacerbations

Exacerbation anua rate

1.1

4

1

# Hospitalization annual

2.6

5

1

Adherence of tiotropium

61%

76%

57%

[18]

Annual discount rate

5.00%

6%

0%