Author, year | Health state | Instrument and data source | Target population | Sample size, mean age | Method of age adjustment |
---|---|---|---|---|---|
Without adjustment of age | |||||
Disease-free Baseline Progression: hormone therapy minor toxicity with chemotherapy major toxicity with chemotherapy | Not reported | 45Â years 65Â years 75Â years 85Â years | 150 Not reported | No | |
 Desch et al. (1993) [24] | Disease-free Well Progression: First recurrence Side effect Minor toxicity with chemotherapy Major toxicity with chemotherapy | Not reported Assumptions | 60 years 65 years 70 years 75 years 80 years | NA | NA |
With adjustment of age | |||||
Skedgel, et al. (2013) [21] | Disease-free: Disease-free baseline varied by age Progression: First local recurrence Second local recurrence Well after relapse Distant recurrence Side effect Congestive heart failure Febrile neutropenia AML/MDS Nausea/vomiting | EQ-5D-3L from previous literature [26] for baseline value Utilities for side effects: from the Cost-Effectiveness Analysis Registry without reporting data source | 40 years 50 years 60 years 70 years 80 + years | 2981, 74 years [26] Not reported for side effects | Partial adjustment: Age-dependent baseline values and fixed progression state values |
 Sen et al. (2014) [20] | 1. Health states Disease-free: Surgery alone Surgery by different adjuvant treatments Progression: Recurrence Distant metastasis 2. Utility modifier 70–74 y 75–79 y 80–84 y  > 85 y | 1.EQ-5D from previous literature [27] 2.Standard gamble from previous literature [69] | 70, 75, and 80 + years | 97 patients with median age at 56 years [27]. Not reported [69] | Disutility multiplier to adjust standard gamble utilities by the mean age-dependent EQ-5D utilities in the general population |
 Ward et al. (2020) [22] and Ward et al. (2019) [23] | 1. Utility Disease-free Baseline 2. Disutility value: Progression Distant metastasis Second malignancy: radiation Induced salvage mastectomy salvage axillary dissection after axillary recurrence Side effect Fracture Second malignancy: endometrial cancer salvage lumpectomy with radiation treatment of contralateral cancer Cardiac adverse event (MI) DVT Acute radiation dermatitis, Grade 3 Hot flashes Arthralgia Late radiation-induced fibrosis | 1. Utility EQ-5D from a cross-sectional U.S. population survey 2005 [28] 2. Disutility from previous economic evaluation [70] | 70 years or older | 965 patients of a sub-cohort aged 65–74 years [28] | Age-dependent baseline values and health-state utilities with an additive utility decrement |