Table 5 Breakdown of annual administration cost of biologics
From: Drug utilization and cost associated with inflammatory bowel disease management in Saudi Arabia
| Â | Cost categories | Biological agents | |||||
|---|---|---|---|---|---|---|---|
Infliximab | Adalimumab | Certolizumab | Golimumab | Ustekinumab | Vedolizumab | ||
Treatment course | Defined daily dose (DDD) | 3.75 mg | 2.9 mg | 14 mg | 1.66 mg | 0.54 mg | 5.4 mg |
Acquisition price per day | 16.5 USD | 44.54 USD | 37.98 USD | 21.98 USD | 12.25 USD | 45.83 USD | |
Route of administration | IV | SubQ | SubQ | SubQ | 1st dose: IV Other doses: SubQ | IV | |
Infusion time | 1st dose = 3Â h other doses = 2Â h | N/A | N/A | N/A | 1 h | 30 min | |
The doses per year | 1st year= 9 doses Next year = 7 doses | 1st year= 27 doses Next year = 26 doses | 1st year=15 doses Next year = 13 doses | 1st year= 14 doses Next year = 13 doses | 1st year= 6 doses Next year = 6 doses. | 1st year= 9 doses Next year = 6 doses | |
Lab tests (all at baseline, and CBC as indicated for each med.) | Tuberculin Test | 46.13 USD | 46.13 USD | 46.13 USD | 46.13 USD | 46.13 USD | 46.13 USD |
Chest X-ray | 53.33 USD | 53.33 USD | 53.33 USD | 53.33 USD | 53.33 USD | 53.33 USD | |
HIV serology | 170.67 USD | 170.67 USD | 170.67 USD | 170.67 USD | 170.67 USD | 170.67 USD | |
Hepatitis B and C serology | 72.80 USD | 72.80 USD | 72.80 USD | 72.80 USD | 72.80 USD | 72.80 USD | |
VZV serology | 114.93 USD | 114.93 USD | 114.93 USD | 114.93 USD | 114.93 USD | 114.93 USD | |
HSV serology | 120 USD | 120 USD | 120 USD | 120 USD | 120 USD | 120 USD | |
CBC | 26.67 USD | 26.67 USD | 26.67 USD | 26.67 USD | 26.67 USD | 26.67 USD | |
U&E, LFT, ESR, serum albumin and CRP | 320 USD | 320 USD | 320 USD | 320 USD | 320 USD | 320 USD | |
| Â | Â | CBC at every administration | CBC every 3 months | CBC every 3 months | CBC every 3 months | CBC every 3 months | CBC at every administration |
|---|---|---|---|---|---|---|---|
Pre-medication (at baseline and at every administration) | Intravenous Infusion procedure | 53.33 USD | 0 USD | 0 USD | 0 USD | 53.33 USD | 53.33 USD |
Normal saline | 0.93 USD | 0 USD | 0 USD | 0 USD | 0.93 USD | 0.93 USD | |
Hydrocortisone IV injection of 100Â mg | 2.17 USD | 0 USD | 0 USD | 0 USD | 2.17 USD | 2.17 USD | |
Chlorpheniramine IV injection of 10 mg | 0.32 USD | 0 USD | 0 USD | 0 USD | 0.32 USD | 0.32 USD | |
Nursing fee per houra | 1st dose = 40 USD Other doses = 26.67 USD | 0 USD | 0 USD | 0 USD | 13.33 USD | 6.66 USD | |
Annual acquisition costb | Annual acquisition cost based on DDD | 6023 USD | 16,258 USD | 13,865 USD | 8025 USD | 4471 USD | 16,730 USD |
Lab tests’ costs | 1138 USD | 1031 USD | 1031 USD | 1031 USD | 1031 USD | 1138 USD | |
IV Pre-medication costs and nursing fee | 744 USD | 0 USD | 0 USD | 0 USD | 70 USD | 556 USD | |
Total cost for the first year of treatment | 7905 USD | 17,289 USD | 14,896 USD | 9056 USD | 5572 USD | 18,424 USD |